Endocrine Abstracts

Patients with histology confirmed acromegaly who have undergone trans-sphenoidal surgery and radiotherapy often have active acromegaly despite no evidence of adenoma on MRI. Currently 111In Octreotide, a radioactive tracer, is used in the assessment of neuroendocrine tumours, with 70-90 percent sensitivity for detection. Studies to date however have not looked at 111In Octreotide as an alternative measure to assess patients who present with biochemically active acromegaly desp...

Type 2 diabetes mellitus (T2DM) is associated with insulin resistance/ hyperinsulinaemia and chronic sub-clinical inflammation that is considered important in the pathogenesis of macrovascular disease. We propose activation of the innate immune system, a biologically conserved first line immune response, within adipose tissue by endotoxaemia secondary to hyperinsulinaemia as one of the causes of this phenomenon. Hyperinsulinaemia may lead to altered gut permeability and result...

Type 2 diabetes (T2DM) is associated with insulin resistance and chronic sub-clinical inflammation. Pro-inflammatory cytokines produced from adipose tissue are secreted as part of the innate immune response and also associated with insulin resistance. In contrast, adipocyte derived adiponectin is associated with insulin sensitivity and also has anti-inflammatory properties. Hence fat may represent a site for mediating the innate immune response. We therefore investigated a mec...